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What Research Studies Have Compared These Two Medications Directly The primary direct comparison is SURMOUNT-5, a randomised controlled trial published in the New England Journal of Medicine (2025), which compared tirzepatide 10mg or 15mg against semaglutide 2.4mg in adults with obesity without diabetes over 72 weeks [10]

Does semaglutide affect skin sensitivity in ways relevant to patch-based testing

Diabetic gastroparesis: evaluation and management

We also measured total GLP-1 and not the active, intact GLP-1 (7-36 amide) levels

Definite benefits of GLP-1 receptor agonists: what is the risk of gastroparesis and lung aspiration

British Journal of Clinical Pharmacology 75979989