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Patients were randomized to receive either weekly subcutaneous semaglutide 2.4 mg or placebo, with the dose gradually increased over 16 weeks to minimize gastrointestinal side effects

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A common approach involves gradually titrating the dose to minimize side effects while maximizing effectiveness

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Gut (2017) 66(2):22634.10.1136/gutjnl-2015-309871 171 FlynnCRAlbaughVLCaiSCheung-FlynnJWilliamsPEBruckerRMet alBile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery
