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Retatrutide works by simultaneously activating three key hormone receptors involved in appetite regulation and energy metabolism: GLP-1 (glucagon-like peptide-1) receptors reducing appetite and slowing gastric emptying GIP (glucose-dependent insulinotropic polypeptide) receptors thought to enhance insulin secretion and potentially support fat metabolism, though the precise contribution in humans is still being investigated Glucagon receptors hypothesised to increase energy expenditure and promote fat breakdown in the liver, based on preclinical and early clinical data This triple mechanism of action is designed to produce more substantial and sustained weight loss compared to single or dual receptor agonists

Retatrutide acts on multiple hormone pathways, which may lead to broader metabolic effects in some individuals

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However, in severe Chronic Kidney Disease (CKD) or dialysis patients, strict medical supervision is required before usage

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and Metabolism 91 (5), 19161923