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Contact your healthcare provider if you experience: Severe or worsening acne that does not respond to basic skincare measures Painful, deep nodules or cysts that may indicate nodulocystic acne requiring prescription therapy Signs of skin infection, including increased warmth, spreading redness, purulent drainage, or fever Allergic reactions such as hives, widespread rash, or facial swelling (call 911 for difficulty breathing or severe allergic reactions) Injection site reactions beyond mild, transient rednessincluding persistent pain, swelling, ulceration, or signs of infection Any rash accompanied by systemic symptoms such as fever, joint pain, or malaise Skin changes that significantly impact quality of life or psychological well-being Your healthcare provider can assess whether observed skin changes represent a medication adverse effect, a manifestation of metabolic changes during treatment, or an unrelated dermatologic condition requiring specific intervention

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