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Description
Strengths Acts via multiple pathways (GLP-1, AMPK, microbiome) Has existing human data showing reductions in fasting glucose, HbA1c, lipids Support receptor expression and islet health Limitations Low absorption and bioavailability Gastrointestinal discomfort is common (diarrhea, cramping)

doi: 10.1097/TP.0000000000005496.

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Novo Nordisk revealed positive Phase 3 data from the PIONEER TEENS trial showing that oral semaglutide significantly reduced blood sugar in children and adolescents aged 1017 with type 2 diabetes, with a safety profile consistent with prior semaglutide studies
