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However, DULs long-term efficacy and safety need to be further studied

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The reason: since the fragment contains only the C-terminal part, it lacks the binding domains for GHR (most of the affinity of hGH for GHR lies in the central part of the molecule)

6 It has a moderately high efficacy, with HbA 1c reductions of up to 14 mmol/mol observed
