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Dehydration and Kidney Injury Gastrointestinal side effects like nausea, vomiting, and diarrhea can lead to dehydration

GLP-1 also reduces appetite and slows the passage of food out of the stomach, making you less hungry after a big meal

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Translation: It may not be the weight loss alone that's to blame for your sagging

BMJ Disease Reviews Finally, a systematic review and meta-analysis in JAMA Neurology (2025) pooling randomized cardiometabolic trials found no overall cognitive/dementia benefit across all cardioprotective diabetes drugs , but GLP-1 RAs stood out with a statistically significant reduction in incident dementia in subgroup analysesimportant but still Can GLP-1 Drugs Help Prevent Dementia