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Matrix metalloproteinases (MMPs) degrade the collagen and other extracellular matrix proteins in thin-cap fibroatheromas, resulting in increased vulnerability of the fibrous cap to mechanical forces in the artery and the potential for plaque rupture and thrombosis [154]

For instance, Hulst et al (2021)178 recommended continuation of all GLP-1RAs therapies throughout the perioperative period

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[Google Scholar] 37.Doi K, Kuroshima A

However, understanding its data matters because it represents where the field is heading

If you take warfarin, more frequent INR monitoring during tirzepatide initiation is advisable