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Most clinical trials measured outcomes at 68 weeks, highlighting that this is a long-term intervention

In fact, a study from the University of Queensland calls fatigue the second-most common side effect of Ozempic

Weight gain

I think the evidence is regardless of impact on HRV, these drugs are beneficial on a longevity basis - but if having side effects, adjust things and go to another drug

Instructions may vary from patient to patient and always verify your dose by checking with your provider, pharmacist, or checking the label on your medication