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That includes proactive management of side effects, candid conversations about the long-term nature of treatment, infrastructure to identify and support patients at risk of stopping and addressing the cost barriers that make GLP-1 therapy unsustainable for many. These measures are especially important, Al-Aly noted, because the cardiovascular protection provided by GLP-1 medication builds slowly, but it erodes quickly

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"For this particular outcome, the symptoms and physical limitations due to heart failure, it's the best results we've gotten with any medication in this type of heart failure so far today, Kosiborod said