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As our knowledge of GLP-1 biology advances and novel therapeutic innovations arise, these agents are expected to assume a progressively pivotal role in the management of metabolic disorders and their related complications, ultimately enhancing patient outcomes across various disease states

This was demonstrated in two randomised controlled trials (RCTs) that showed a decrease in epicardial adipose tissue in patients with T2D and obesity on liraglutide and exenatide according to echocardiography and cardiac MRI

Orlistat is a lipase inhibitor

While our recent report has shown that over 7% of all prescriptions are for GLP-1-based therapies ( 8 ), oral formulations may lower barriers to initiation by offering a non-injectable option that can be prescribed and managed in a broader range of clinical settings

This sudden shift highlights why a gradual tapering process can make all the difference

Theres also a lot less maintenance with the shot