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A National Institutes of Health (NIH)-funded study has found that an emerging class of GLP-1 weight loss drugs suppress eating for pleasure, or hedonic feeding, in mice by modulating a reward circuit deep within the brain

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Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion

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