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for 5 consecutive days resulted in a significant amelioration of animal weight loss, reduction of histopathological inflammation score, and myeloperoxidase levels compared with control mice

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Given the small sample size, absence of a comparator group, lack of formal event adjudication, and limited statistical power, no conclusions regarding cardiovascular benefit or harm can be drawn

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This approach may be more widely useful as a conformational sensor for other GPCRs, although it lacks the ability to detect changes at the receptor intracellular face that are needed to provide insights into conformational changes required for G protein interactions