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Evidence for digestive benefits in humans is limited but suggestive: papaya preparations containing papain have been associated with improved subjective digestion and reduced bloating in small studies, though fiber and other compounds in papaya likely contribute as well.26 Fiber-targeting enzymes (cellulase and related carbohydrases) Enzymes like cellulase, hemicellulase, xylanase, -glucanase, and pectinase are often grouped as fiber-targeting enzymes because they act on components of plant cell walls.27 28 Humans dont make most of these enzymes