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Treatment follows a stepwise approach starting with dietary modification: reducing simple carbohydrates, increasing protein and healthy fats, and eating smaller frequent meals

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MECHANISMS OF ACTION OF GLP-1 RAs AND MULTI-AGONIST THERAPIES Incretin-based therapies leverage the physiological roles of gut-derived peptide hormones, principally glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptor (GCG) to address the multifaceted pathophysiology of MASLD

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Breaking this cycle by prioritizing sleep hygiene, consistent bedtimes, cool bedroom temperature, limiting screens before bed, often produces surprisingly broad improvements across multiple symptom categories

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