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Description

Currently, Saxenda (Liraglutide - NVO) and Wegovy (Semaglutide - NVO) are the two GLP-1 drugs approved for weight loss by the FDA

[53] In two of these (NCT03954834 and NCT04039503), participants were randomly assigned to receive either tirzepatide or placebo injection weekly

While GLP-1 receptor agonists (GLP-1-RA) directly target GLP-1, GLP-1-independent effects are also possible with the use of DPP4 inhibitors (DPP4i)

These developments favor therapeutic modalities, such as peptides, that can be mechanistically linked to disease pathways and monitored through pharmacodynamic readouts

Prioritize protein, but choose gentler options when nausea is active, such as Greek yogurt, eggs, cottage cheese, smoothies, soups with soft protein, fish, tofu, or shredded chicken