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retatrutide phase 2 weight loss π¨Breaking: Retatrutide's first 3 T2D data just dropped. βΈ A1C: β2.0% at 40 weeks βΈ Weight: β36.6 lbs (β16.8%) at 12 mg βΈ No plateau β curve still descending The loudest people online are
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Also, on a more serious note, retatrutide raising your heart rate is annoying and mildly concerning
No one has more experience working with patients on GLP1 meds than myself

Nat Rev Neurol 20(4): 245251

The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis

That tension is a door cracked wide open for startups
Small, steady increases in time or intensity are safer and more effective than big leaps