has retatrutide been approved vs. Tirzepatide: What's the Difference? Semaglutide vs. Retatrutide: A Comparison
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Karagiannis T et al (2017): Canagliflozin in the treatment of type 2 diabetes: an evidence-based review of its place in therapy

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CLINICAL PRACTICE CONSIDERATIONS Long-term outcomes While strong evidence supports the kidney-protective effects of both SGLT2 inhibitors and GLP-1 receptor agonists, the long-term durability of these benefits remains uncertain (Table 2)

The latest example is the buzz around retatrutide, or Reta, as its trending on TikTok
In studies using the Duchenne muscular dystrophy mouse model ( mdx ), both the genetic crossing of mdx mice with Mstn / mice and the administration of the MSTN-neutralizing antibody mRK35 led to similar outcomes, specifically increased muscle mass and improved grip strength.[24,25] However, another mouse study reported that Mstn / mice, despite having increased muscle mass, did not exhibit a corresponding increase in muscle strength.[26] Although there are conflicting results regarding the ability of MSTN inhibition to improve muscle functions, such as muscle strength, most studies consistently show that inhibition of MSTN results in a significant increase in muscle mass

So the question is real
