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In the ATTAIN-MAINTAIN trial, orforglipron's profile was "consistent with previous orforglipron Phase 3 studies." The most common adverse events were gastrointestinal-related and were generally mild-to-moderate in severity, which is expected for the GLP-1 class

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Common GLP-1 receptor agonist medications include semaglutide drugs such as Ozempic, Wegovy, and Rybelsus, as well as tirzepatide medications including Mounjaro and Zepbound

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