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Diabetes and Cardiovascular Disease: The Potential Benefit of Incretin-Based Therapies

Effectively suppressing the production of pro-inflammatory cytokines, adhesion molecules, and chemokines, GLP-1RAs may attenuate the inflammatory response by decreasing NF-B signaling

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Wegovy is a higher-dose formulation of semaglutide primarily used for weight management

Currently three of those medications, Zepbound, Wegovy and Saxenda, are FDA-indicated for weight-loss assistance

GLP-1RA treatment also mitigates experimental diabetic cardiomyopathy by the indirect mechanisms of augmenting glucose oxidation in cardiomyocytes [84]