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Tirzepatide targets both GLP-1 and GIP receptors, which earned it the "dual agonist" designation

GLP-1 weight loss medications are ideal for individuals who: Have a BMI of 30 or higher

To recover GcgR activity, the introduction of a lactam bridge between Glu16 and Lys20 promoted secondary structure stabilization and balanced GLP-1R/GcgR activity

To date, exenatide, liraglutide, albiglutide, lixisenatide, and dulaglutide, which are structurally modified GLP-1 analogs with extended half-life in vivo, are used in a clinical setting (Gupta et al

"GLP-1 medications are intriguing from a cancer research perspective because they weren't designed for cancer therapy, but they do affect many different targets and pathways associated with cancer development, so we're eager to study them in this context," McDonald said

However, oral bioavailability is only about 1%, meaning you need a much higher absolute dose to achieve comparable blood levels to the injectable form