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Patients with advanced disease (mean diabetes duration 1315 years) on insulin who required additional treatment were studied in SUSTAIN 5 and PIONEER 8 (20, 26)

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Moreover, in each group, participants who lost 5% or more weight represented 52.0%, 88.2%, 92.0%, 91.8%, and 10.2%, respectively

One of the most potent SCFAs is butyrate, which is generated by the microbial fermentation of prebiotic fibers

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