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Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione core

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Kseolu D., zdemir Baer ., Berker D., Gler S

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your body creates a hormone called ghrelin that sends signals to your brain to eat

Illant Health CEO Elina Onitskansky said the results were "incredibly exciting" but offered some reasons in a LinkedIn post as to why these results may be different than other studies