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This study evaluates insulin resistance by HOMA-IR index

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Evaluating semaglutide and tirzepatide in early non-responders While semaglutide produces 15-17% mean weight loss and tirzepatide yields even more impressive 16-22.5% reductions, neither has been thoroughly evaluated in early non-responders

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While these medications play a role in metabolic care, they also introduce significant clinical considerations, particularly for individuals with current or past eating disorders