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Mechanisms of NMDA receptor- and voltage-gated l-type calcium channel-dependent hippocampal LTP critically rely on proteolysis that is mediated by distinct metalloproteinases

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In adults with BMI 27 kg/m2 and type 2 diabetes, adding tirzepatide to a lifestyle intervention increased weight loss at 72 wk
Tirzepatide also comes with a boxed warning: Tirzepatide is contraindicated in patients with medullary thyroid cancer

With regard to the unique clinical context of OSAS, no evidence currently suggests that tirzepatide exacerbates sleep apnea symptoms or induces severe hypoxemic events (58)