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Food significantly reduces oral medication absorption, whereas injections avoid the digestive system entirely

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During the intensive lifestyle intervention lead-in period, lifestyle instruction was delivered 8 times over 12 weeks by a dietician or dietician-equivalent, with all patients receiving instruction to exercise for at least 150 minutes per week and to reduce their caloric intake to approximately 1,200 kcal/day (females) or 1,500 kcal/day (males)

doi: 10.1046/j.1471-4159.1996.67051982.x

The honest summary: per-compound trial data are strong