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MacIsaac RJ, Ekinci EI, Jerums G

LPL is also inhibited by angiopoietin-like 4 (ANGPTL4), a dominant regulator of LPL activity

In fasted rats, co-administration of GLP-1 and GLP-2 leads to a greater inhibition of small bowel motility relative to either monotherapy [793]

For patients with non-alcoholic fatty liver disease or non-alcoholic steatohepatitis, tirzepatide represents one of the most effective interventions currently available

However, the mechanism of GLP-1R in treating obesity is still uncertain, and more clinical evidence is needed for its long-term safety and efficacy