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Separate and Combined Glucometabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide 1 in Healthy Individuals

[4] For weight management, clinically meaningful weight loss is generally defined as 5% or more of initial body weight

Theres a second issue: GLP-1 drugs can trigger the release of enzymes that are associated with pancreatic disorders

The mature form of DPP4 is secreted as a monomer, but it dimerizes to exhibit proteolytic activity [38]

Moreover, peptides in GLP-1 drugs are derived from living cells through recombinant DNA technology, which makes their manufacturing process more complex and expensive than traditional pills

Hemmer, A., Maiter, D., Buysschaert, M., & Preumont, V