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If these mechanisms translate consistently into humans, this could reshape how we think about patient selection and treatment goalsespecially in individuals who may not achieve substantial weight reduction but still derive meaningful hepatic benefit

Exocrine pancreatic function modulates plasma metabolites through changes in gut microbiota composition

Weight loss during this period averages 3-4%, primarily reflecting reduced caloric intake rather than major metabolic changes

It works by slowing food movement through the stomach, which may decrease appetite and cause weight loss