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While utilizing GLP-1Ras in patients with diabetes or underlying cardiovascular disease were demonstrated to have diverse benefits, such as reductions in HbA1c levels, blood pressure control, improving endothelial function, and enhancing the lipid profile [80,81,82], our meta-analysis focused exclusively on weight-related outcomes

They did find a higher rate of RGC (OR 5.56, 95% CI 3.35 to 9.23) and rates of abandonment of procedures (OR 5.13, 95% CI 3.01 to 8.75)

These medications appear to reduce the production of pro-inflammatory cytokinessignalling molecules that drive inflammationsuch as tumour necrosis factor-alpha (TNF-), interleukin-6 (IL-6), and interleukin-1 beta (IL-1)

It decreases leptin, the satiety hormone, by a similar amount

By focusing exclusively on RCTs, our findings offer greater internal validity and minimize confounding and selection bias

These data indicate that GLP-1 receptor agonistinduced changes in local adipose tissue depots or parenchymal fat accumulation may contribute to their ability to protect the kidneys