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Some people carry genetic variants associated with heightened GLP-1 pathway activation, potentially increasing the likelihood of rapid appetite loss and metabolic adaptationboth contributors to fatigue

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The observed effects were consistent in all investigated subgroups, with a trend toward stronger effects in subjects with T2D and higher cardiovascular risk (77)

The net effect on libido likely varies considerably among individuals based on baseline health status, the magnitude of weight loss, and psychological factors

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