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In patients who remained on tirzepatide 7.5 mg, escalation to 10 mg was not pursued based on clinical judgment, considering factors such as previous response and patient preference during routine care

This is a significant gap in understanding how these drugs impact metabolic rate and daily calorie expenditure, which is a key aspect of long-term weight management

Orals are not just another formulation. They are the first credible attempt to make GLP-1 mass-market scalable in the way statins or antihypertensives wereif efficacy, safety, and supply can hold

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