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For small molecules with active P.IV litigation, estimate the probability of generic success based on: the specific invalidity grounds alleged (obviousness challenges succeed more often than written description challenges), the quality of the primary patent examiners prosecution history (patents with a thorough prosecution history and considered prior art rejections are harder to invalidate), the generic companys litigation history and financial capacity, and the judicial district and assigned judge for the case

10.1038/nrgastro.2016.107 [DOI] [PMC free article] [PubMed] [Google Scholar] Rebosio C., Balbi M., Passalacqua M., Ricciarelli R., Fedele E

The neighboring residue D198 2.68b has also been mutated by several groups: Xiao et al

Hansen KB, Rosenkilde MM, Knop FK, Wellner N, Diep TA, Rehfeld JF, Andersen UB, Holst JJ, Hansen HS

Research on GLP-1 therapy discontinuation suggests that certain metabolic improvements show partial persistence even after weight regain

Prog Neurobiol (2005) 76:7798