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max dose 200mg q12hr Dantrolene: muscle relaxant for cases with extreme rigidity, use in combination (not as monotherapy) with dopaminergic agents in severe cases 1-2.5 mg/kg initially followed by 1mg/kg q6hrs Disposition NMS can be very severe and usually requires ICU level care

Overall, men typically present earlier with a classic MASLD phenotype-central obesity, IR, dyslipidemia, and hypertension [166] -while women may develop MASLD with fewer overt metabolic abnormalities, influenced by menopause, PCOS, or lean MASLD phenotypes characterized by adipose dysfunction, sarcopenia, and altered bile acid signaling [193,201,202]

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