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Clinical data shows that approximately 25% of weight lost on GLP-1 medications comes from lean mass, making muscle preservation strategies increasingly relevant for researchers exploring optimal body composition outcomes

While a full discussion of the mechanisms behind GLP-1RA-mediated CV risk reduction is beyond the scope of this article, we note that the interaction P-values suggest no difference in the treatment effect on CV outcomes when semaglutide is used with or without metformin

Benefits Beyond Weight Loss In addition to significant weight reduction, semaglutide offers other health benefits, such as: Improved blood sugar control, which is particularly valuable for individuals with prediabetes or type 2 diabetes

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Orphan drug exclusivity, if applicable for specific indications, can add an additional seven years of market protection

11 In addition, other factors have been assumed to be associated with the action of GLP-1 receptor agonists (Figure 1)