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You will likely not have any issues as the medication can last in the system for up to eight weeks, she says

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Handling and Safety Warnings WARNING: RESEARCH USE ONLY

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When Weight Loss Picks Up Again If youre switching because of a semaglutide plateau, realistic timing matters

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American Society of Clinical Oncology (ASCO) Annual Meeting 2026

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If a patient cannot tolerate dose escalation at any stage, the FDA allows staying on the prior tolerated dose and delaying escalation instead of discontinuing therapy

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SURMOUNT-5 found that tirzepatide produced 20.2% mean weight loss versus 13.7% with semaglutide over 72 weeks in adults with obesity without diabetes a statistically significant 6.5 percentage point difference [10]

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