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doi: 10.1016/j.metabol.2021.154871, PMID: [DOI] [PubMed] [Google Scholar] 50

For these patients, insulin therapy with Tresiba may be the preferred option for glucose control

Most clinical trials for these weight loss medications have excluded patients with significant gastrointestinal diseases, including active IBD

AMG 133 (maridebart cafraglutide) is a bispecific molecule engineered by conjugating a fully human monoclonal anti-human GIPR antagonist antibody to two GLP-1 analogue agonist peptides using amino acid linkers

On the other hand, there are also some real significant and potentially dangerous side effects that surfaced in clinical trials

12,13 GLP-1 RAs are recommended in the treatment guidelines by the American Diabetes Association as well as the American Association of Clinical Endocrinology (AACE) Consensus Statement & European Society of Cardiology for type 2 diabetes mellitus patients with co-morbidities, like established atherosclerotic cardiovascular disease and obesity