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Semaglutide presents a pronounced weight-lowering effect, mediated by direct GLP-1 stimulation of the anorexigenic (satiety inducers) proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) neurons along with indirect inhibition of orexigenic neurons (appetite inducers) neuropeptide Y (NPY) and agouti-related peptide (AgRP), located in the arcuate nucleus (ARC) in the hypothalamus, which is vital in the regulation of appetite and energy balance [114,115,116]

They dont replace these medications, but the required dose may go down

S., Christensen, S

Wegovy pens contain needles and are considered sharps waste

This systematic review aimed to evaluate the evidence on GLP-1RAs immune-modulating role in IBD and other IMIDs

Gastroenterology 143, 765776.e3