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Survodutide also reduced waist circumference, an indicator of metabolic health.

In patients with obesity (mean age 51.3 years, 65.6% women), semaglutide compared with non-GLP-1RA anti-obesity medications was associated with lower risk for incident CUD in patients with no prior history CUD (HR: 0.56, 95% CI: 0.420.75), and recurrent CUD diagnosis in patients with a prior history CUD (HR: 0.62, 95% CI: 0.460.84)

NAION is rare: doctors diagnose about 6,000 new cases of it every year in the United States, which has a population of 340 million people

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A 2024 RCT found semaglutide reduced hip bone density by 2.6% and lumbar spine by 2.1% in one year
