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In the quest to shed extra pounds, weight loss drugs like GLP-1 agonistssuch as Ozempic, Wegovy, and Mounjaroare rising stars

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Next-generation injectables: Retatrutide (Eli Lilly's triple agonist targeting GIP/GLP-1/glucagon) has shown up to 24.2% weight loss in Phase 2 and is in Phase 3 development

Some research suggests fasting may upregulate endogenous GLP-1 secretion, though the clinical significance of this in the context of pharmacological GLP-1 doses is unclear

also, there is no longer support for the skin over these areas, so it sags and wrinkles
