can semaglutide cause rapid heartbeat Side Effects: What Patients Should Know in 2025 Semaglutide in Cardiometabolic Diseases: SELECTing

For others, it may cause stronger nausea, dizziness, reflux, dehydration, or next-day fatigue

Incretin-based therapies

In May 2025, the FDA warned the public about unapproved or compounded semaglutide risks, noting the agency has not reviewed these products for safety, quality or effectiveness

The FDAs warning letters come as the shortage status of Eli Lillys tirzepatidemarketed as Mounjaro for type 2 diabetes and as Zepbound for chronic weight managementremains in limbo, enabling compounding pharmacies to legally continue making versions of the drugs

Compounded medications are not equivalent to or interchangeable with FDA-approved brand-name GLP-1 drugs

GLP-1Rs are not only widely expressed in the central nervous system but also in peripheral nerves such as vagal afferents