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The SELECT trial (The New England Journal of Medicine, 2023) studied over 17,600 adults aged 45 and older with overweight or obesity and established cardiovascular disease but not diabetes

If your semaglutide protocol is interfering with restful sleep, the glycine component provides a small but meaningful boost to sleep architecture

Brain-derived neurotrophic factor (BDNF) is important for neurogenesis, and various depressive symptoms arise from decreased BDNF levels (Sahay and Hen, 2007)

Higher than that is not recommended

Diet and Exercise: Semaglutide isn't a standalone solution

The cardiometabolic case for GLP-1 receptor agonists in established disease is now strong on the evidence side, not the marketing side