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7 , 9 , 10 Liraglutide and OW semaglutide have indications for patients with T2D and established CV disease, whereas the indication for dulaglutide is for patients with T2D and established CV disease or multiple CV risk factors

Still, 21% of adults say they are not familiar at all with the medication

Important Limitations of Use : [1] Not recommended as first-line therapy for patients inadequately controlled on diet and exercise

(2025).* Zepbound (tirzepatide) prescribing information*

SGLT-2 inhibitors act primarily in the renal proximal tubule and have no established direct actions on mesolimbic reward circuits in the brain.63 On the contrary, neurotropism is a distinct property of GLP-1 receptor agonists.62 GLP-1 is produced in the brain, GLP-1 receptors are present in areas of the brain involved in impulse control and reward signalling, and a pharmacologically administered exogenous GLP-1 receptor agonist crosses the blood-brain barrier and enters the brain within minutes, strengthening the inference that the observed GLP-1 receptor agonist anti-addictive properties are likely specific and biologically plausible drug effect of GLP-1 receptor agonism, distinct from the general benefits of treating diabetes that would be expected with both SGLT-2 inhibitors and GLP-1 receptor agonists.6465 These observational findings do not by themselves justify the prescribing of GLP-1 receptor agonists specifically to prevent or treat SUDs