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GLP-1R in Mesocorticolimbic Reward and Relapse Circuits The mesocorticolimbic DA system, encompassing the VTA, NAc, and PFC, plays a central role in mediating reward, reinforcement learning, and compulsive drug-seeking

[2] Patients should maintain consistent hydration when increasing protein intake, as adequate fluid consumption supports renal function and helps prevent constipation, another potential side effect of GLP-1 receptor agonists

Some studies explored even higher doses, like 50 mg once daily, and saw slightly more weight loss

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GLP-1s have proven effective at helping people lose weight and get their blood sugar under control, potentially reducing the risk of heart attacks, strokes and other serious health conditions