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Briefly, a closed testing procedure that operated based on an overall significance level of alpha = 0.05 was allocated to the initial test, which was either a test of non-inferiority for SEM 14 mg compared to active comparators (empagliflozin in PIONEER 2 and sitagliptin in PIONEER 3) or a test of superiority for SEM 14 mg compared to placebo (PIONEER 1, 4, and 8)

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It may slightly slow absorption, but this is generally not clinically meaningful

Similar content being viewed by others Introduction The increasing global incidence of obesity is a major public health concern, escalating at a concerning rate and posing significant challenges to healthcare systems worldwide 1

11 Consult an endocrinologist for recommendations to bridge antidiabetic therapy if GLP-1 receptor agonists prescribed for diabetes management are to be held for longer than the next scheduled dosing time