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The Guardian also reported on Phase 3 trial results showing substantial average weight loss among adults with obesity or overweight, while noting common gastrointestinal side effects such as nausea, vomiting, diarrhea, and constipation

This trend is driving broader prescribing practices beyond endocrinology into primary and cardiovascular care

The Phase II trials of Retatrutide have generated excitement by showcasing weight loss outcomes of up to 24% over an 11-month period

Early research suggests GLP-1 activation may reduce neuroinflammation and modulate pain perception through multiple biological pathways, potentially offering relief where traditional pain medications have failed