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Purpose of Review This review explores the rationale and available evidence behind incretin-based therapies for metabolic dysfunction-associated steatotic disease (MASLD) and metabolic-associated steatohepatitis (MASH), focusing on glucagon-like peptide 1 (GLP-1) and glucagon (GCG) receptor dual agonists (GLP-1/GCG RAs)

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The glucagon-like peptide-1 receptor (GLP-1R) is a class B G proteincoupled receptor that regulates glucose homeostasis by promoting cAMP production and insulin secretion in pancreatic -cells

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