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That second finding suggests that lowering stress hormones may actually help reset the brain to defend a lower body weight, which could be transformative

Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

However, what we produce has a circulating half-life of 2 minutes in our blood stream
While more study is needed, some addiction specialists prescribe them as an adjunct to behavioral and lifestyle treatments
PLoS One 8 , e77284 (2013)

doi: 10.1016/j.peptides.2019.170230 [DOI] [PubMed] [Google Scholar] 9.Yamada Y, Seino Y