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Johnson JA, Simpson SH, Toth EL, Majumdar SR: Reduced cardiovascular morbidity and mortality associated with metformin use in subjects with Type 2 diabetes

doi: 10.1210/en.2013-1934 193 PanjwaniNMulvihillEELonguetCYustaBCampbellJEBrownTJet al

However, discontinuation often leads to weight regain and loss of cardiometabolic benefits, 42 , 87 suggesting that, as with traditional antihypertensive drugs, sustained BP control may require ongoing use

First-line therapies, including metformin, sodium-glucose cotransporter-2 inhibitors (SGLT-2i), and Glucagon-like peptide-1 (GLP-1) receptor agonists, are selected according to patient-specific risk factors