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1 Nearly half of the study participants lost 20% or more of their body weight, while 26.1% reached weight loss of 30% or greater

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GLP-1 has a very brief half-life (less than 2 min) owing to the swift deactivation of the commonly proteolytic enzyme dipeptidyl peptidase-4 (DPP-4), which leads to the emergence of GLP-1 receptor agonists (GLP-1RAs), which are GLP-1 analogs with extended half-lives and ongoing biological activity (Ma et al

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Gastrointestinal Adverse Reactions In the pool of placebo-controlled trials, gastrointestinal adverse reactions occurred more frequently among patients who received RYBELSUS than placebo: RYBELSUS 14 mg once daily (41%), RYBELSUS 7 mg once daily (32%) and placebo (21%), including severe reactions (RYBELSUS 14 mg 2.0%, RYBELSUS 7 mg 0.6%, placebo 0.3%)